Computer programs used in the field of hospital pharmacy for the management of dangerous drugs: systematic review of literature.

Background: This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy services that pose a risk to the healthcare personnel who handle them. Objective: To review the scientific literature to determine what computer programs have been used in the field of hospital pharmacy for the management of dangerous drugs (HDs). Methods: The following electronic databases were searched from inception to July 30, 2021: MEDLINE (via PubMed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The following terms were used in the search strategy: "Antineoplastic Agents," "Cytostatic Agents," "Hazardous Substances," "Medical Informatics Applications," "Mobile Applications," "Software," "Software Design," and "Pharmacy Service, Hospital." Results: A total of 104 studies were retrieved form the databases, and 18 additional studies were obtained by manually searching the reference lists of the included studies and by consulting experts. Once the inclusion and exclusion criteria were applied, 26 studies were ultimately included in this review. Most of the applications described in the included studies were used for the management of antineoplastic drugs. The most commonly controlled stage was electronic prescription; 18 studies and 7 interventions carried out in the preparation stage focused on evaluating the accuracy of chemotherapy preparations. Conclusion: Antineoplastic electronic prescription software was the most widely implemented software at the hospital level. No software was found to control the entire HD process. Only one of the selected studies measured safety events in workers who handle HDs. Moreover, health personnel were found to be satisfied with the implementation of this type of technology for daily work with these medications. All studies reviewed herein considered patient safety as their final objective. However, none of the studies evaluated the risk of HD exposure among workers.

Converter Phenotype: A New Profile That Is Not Exclusive to Taxanes.

Introduction: Phenotype I hypersensitivity reactions are the most commonly reported drug reactions; however, precision medicine has made it possible to characterize new phenotypes. A recent communication proposed the existence of a "converter phenotype," which would affect patients who present non-immediate hypersensitivity reactions and in subsequent exposures develop immediate hypersensitivity reactions. This study aimed to describe the clinical characteristics of converter phenotype reactions and their evolution during desensitization to chemotherapeutic drugs and monoclonal antibodies. Methods: We retrospectively reviewed our database of patients undergoing desensitization to chemotherapy or biological agents and selected those with a converter phenotype. Demographic and clinical characteristics of the patients, the results of skin tests, tryptase and IL-6 levels, and desensitization outcomes were assessed. Results: Of 116 patients evaluated, 12 (10.3%) were identified as having a converter phenotype. The median interval between drug exposure and reaction was 90.6 h (range 8-288 h). After the conversion, phenotype I was the most frequent (58.3%), followed by cytokine release reactions (33.3%). Fifty-one desensitizations were undertaken and all treatments completed, with 10 (19.6%) breakthrough reactions. No new changes in the phenotype were detected. Conclusions: The symptoms of non-immediate drug hypersensitivity reactions may indicate the need for an early allergological evaluation to assess the risk of future immediate drug reactions. Clinical characteristics, skin test results, and biomarkers can help predict responses to rapid drug desensitization, guiding clinicians on how to optimize therapy delivery while maintaining patient safety.

Hospital Pharmacy: Comprehensive management of medical devices during SARS-CoV-2.

Medical devices have become essential to the prevention and control of the  COVID-19 pandemic, being crucial for health professionals and patients in  particular, and the population in general. It is important to be aware of the laws  that regulate the management, distribution, and control of medical devices.  Article 82 of the Spanish Law 29/2006 on Guarantees and Rational Use of  Medicines and Medical Devices establishes that it is the responsibility of Hospital  Pharmacy Services "to participate in and coordinate the purchase of medicines and medical devices in the hospital to ensure an efficient acquisition  and rational use of medical devices". For this reason, working groups of the Spanish Society of Hospital Pharmacy and other scientific societies have issued technical guidelines and consensus statements to provide technical support and updated information on the use of masks, individual  protection equipments and other medical devices. In addition, the shortage of  medical devices caused by the high demand has resulted in the uncontrolled  production and distribution of medical devices. This phenomenon, added to the  fraudulent selling of medical devices, highlights the need for a closer surveillance of the market to guarantee the efficacy and safety of available medical devices. A rational use of medical devices is necessary to ensure the availability and safety of these products, which requires the involvement of  different stakeholders, including hospital pharmacists. Thus, it is essential that  hospital pharmacists receive specific training in technical aspects concerning the possession and use of medical devices. This will help guarantee an effective and safe use of medical products. The acquisition and use of medical  devices requires a keen understanding of the technical and legal aspects  concerning these products, which makes hospital pharmacists essential for the  integral management of medical devices.

Los productos sanitarios se han convertido en imprescindibles en la prevención y control de la pandemia actual generada por COVID-19, tanto para el personal  sanitario y pacientes, como para la ciudadanía en su totalidad. Los productos  sanitarios cuentan con una legislación propia que es preciso conocer para su  correcta gestión, distribución y control. El artículo 82 de la Ley 29/2006 de  garantías y uso racional de los medicamentos y productos sanitarios establece  que es responsabilidad de los servicios de farmacia hospitalaria "participar y  coordinar la gestión de las compras de los productos sanitarios del hospital a  efectos de asegurar la eficiencia de la misma y así contribuir al uso racional de  los mismos". Por este motivo, grupos de trabajo de expertos de la Sociedad Española de Farmacia Hospitalaria, junto a otras sociedades científicas, han desarrollado durante esta pandemia documentos técnicos y consensos para dar soporte técnico e informativo de forma actualizada en  relación con las mascarillas, los equipos de protección individual y otros  productos sanitarios. Por otro lado, los problemas de desabastecimiento  secundarios a la elevada demanda han llevado a una producción y  comercialización descontrolada de productos sanitarios. Este hecho, asociado a  la comercialización fraudulenta de productos sanitarios en el mercado, ha  generado la necesidad de una vigilancia exhaustiva, capaz de garantizar la  eficacia y seguridad de los productos sanitarios en circulación. El uso racional,  para asegurar la disponibilidad y seguridad de los productos sanitarios, es una  responsabilidad multidisciplinar compleja. Para ello, es fundamental una  formación específica como la del farmacéutico de hospital en aspectos técnicos  de tenencia y uso que permite salvaguardar las garantías de eficacia, seguridad  y calidad de los productos sanitarios. El conocimiento técnico y legal que  requieren los productos sanitarios hace imprescindible la implicación del  farmacéutico de hospital como uno de los profesionales sanitarios capacitado  para la gestión integral de estos productos.

El servicio de farmacia: Gestión integral de productos sanitarios en SARS-CoV-2 / Hospital Pharmacy: Comprehensive management of medical devices during SARS-CoV-2

Los productos sanitarios se han convertido en imprescindibles en la prevención y control de la pandemia actual generada por COVID-19, tanto para el personal sanitario y pacientes, como para la ciudadanía en su totalidad. Los productos sanitarios cuentan con una legislación propia que es preciso conocer para su correcta gestión, distribución y control. El artículo 82 de la Ley 29/2006 de garantías y uso racional de los medicamentos y productos sanitarios establece que es responsabilidad de los servicios de farmacia hospitalaria “participar y coordinar la gestión de las compras de los productos sanitarios del hospital a efectos de asegurar la eficiencia de la misma y así contribuir al uso racional de los mismos”. Por este motivo, grupos de trabajo de expertos de la Sociedad Española de Farmacia Hospitalaria, junto a otras sociedades científicas, han desarrollado durante esta pandemia documentos técnicos y consensos para dar soporte técnico e informativo de forma actualizada en relación con las mascarillas, los equipos de protección individual y otros productos sanitarios. Por otro lado, los problemas de desabastecimiento secundarios a la elevada demanda han llevado a una producción y comercialización descontrolada de productos sanitarios. Este hecho, asociado a la comercialización fraudulenta de productos sanitarios en el mercado, ha generado la necesidad de una vigilancia exhaustiva, capaz de garantizar la eficacia y seguridad de los productos sanitarios en circulación. El uso racional, para asegurar la disponibilidad y seguridad de los productos sanitarios, es una responsabilidad multidisciplinar compleja. Para ello, es fundamental una formación específica como la del farmacéutico de hospital en aspectos técnicos de tenencia y uso que permite salva-guardar las garantías de eficacia, seguridad y calidad de los productos sanitarios. El conocimiento técnico y legal que requieren los productos sanitarios hace imprescindible la implicación del farmacéutico de hospital como uno de los profesionales sanitarios capacitado para la gestión integral de estos productos

Medical devices have become essential to the prevention and control of the COVID-19 pandemic, being crucial for health professionals and patients in particular, and the population in general. It is important to be aware of the laws that regulate the management, distribution, and control of medical devices. Article 82 of the Spanish Law 29/2006 on Guarantees and Rational Use of Medicines and Medical Devices establishes that it is the responsibility of Hospital Pharmacy Services “to participate in and coordinate the purchase of medicines and medical devices in the hospital to ensure an efficient acquisition and rational use of medical devices”. For this reason, working groups of the Spanish Society of Hospital Pharmacy and other scientific societies have issued technical guidelines and consensus statements to provide technical support and updated information on the use of masks, individual protection equipments and other medical devices. In addition, the shortage of medical devices caused by the high demand has resulted in the uncontrolled production and distribution of medical devices. This phenomenon, added to the fraudulent selling of medical devices, highlights the need for a closer surveillance of the market to guarantee the efficacy and safety of available medical devices. A rational use of medical devices is necessary to ensure the availability and safety of these products, which requires the involvement of different stakeholders, including hospital pharmacists. Thus, it is essential that hospital pharmacists receive specific training in technical aspects concerning the possession and use of medical devices. This will help guarantee an effective and safe use of medical products The acquisition and use of medical devices requires a keen understanding of the technical and legal aspects concerning these products, which makes hospital pharmacists essential for the integral management of medical devices